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Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's Energetic metabolites. The impact of CYP3A4 inducers on cariprazine publicity hasn't been evaluated as well as the Web effect is unclear.pentobarbital will lower the extent or influence of doravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentob